// Synthetic & Evolutionary Biology

Designing evolution for discovery and biotechnology.

Our lab combines synthetic and evolutionary biology to study both fundamental and applied questions using microorganisms. We design biological systems with state-of-the-art synthetic tools and pair them with experimental and directed evolution — to understand why a given phenomenon arises, and how it can be used to solve real-world problems.

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From synthetic design to fundamental and applied questions
// 00 — Research highlights

The Story Behind the Paper

This video was AI-generated as an accessible summary. For accurate scientific detail, please read the original papers below.

// 01 — Focus areas

Research Directions

001

Rules of Microbial Division of Labour

We investigate how and why division of labour emerges among microbes, and the conditions that favour cooperation over generalist strategies. Building on our work describing division-of-labour traits in nature, we now use synthetic biology to reshape these systems and probe their underlying principles.

002

Division of Labour for Biotechnology

Industrial bioprocesses rely on either single strains or multi-strain consortia, and each strategy carries its own limitations. Working with industrial partners, we apply evolutionary theory to understand and overcome these challenges in real-world production settings.

003

AI-Guided Design Meets Evolution

We combine AI-guided molecular design with experimental and directed evolution to test long-standing questions in evolutionary biology. This lets us build tailored biological systems and use them as precise tools to probe how living systems adapt.

// 02 — People

Team

Zheren Zhang
Zheren Zhang
Principal Investigator · Lecturer in Biotechnology
Jakub Medrek
Jakub Medrek
MSc Student
Stuti Banerjee
Stuti Banerjee
MSc Student
Nandini Pandey
Nandini Pandey
MSc Student
// 03 — Selected work

Publications

bioRxiv · Preprint · 2025
Divergent spontaneous antibiotic-resistance evolution confers reciprocal and exploitable collateral sensitivity effects
A. Liakopoulos, S. T. Tandar, I. V. Hoogendijk, E. Fragkiskou, Z. Zhang, B. Vriesendorp, L. B. S. Aulin, J. G. C. van Hasselt, D. E. Rozen
DOI
Nature Communications · 2022
Mutational meltdown of putative microbial altruists in Streptomyces coelicolor colonies
Z. Zhang, S. Shitut, B. Claushuis, D. Claessen, D. E. Rozen
DOI
Science Advances · 2020
Antibiotic production in Streptomyces is organized by a division of labor through terminal genomic differentiation
Z. Zhang, C. Du, F. de Barsy, M. Liem, A. Liakopoulos, G. P. van Wezel, Y. H. Choi, D. Claessen, D. E. Rozen
DOI
Antonie van Leeuwenhoek · 2020
Genome rearrangements and megaplasmid loss in the filamentous bacterium Kitasatospora viridifaciens are associated with protoplast formation and regeneration
K. Ramijan, Z. Zhang, G. P. van Wezel, D. Claessen
DOI
Nature Communications · 2018
Stress-induced formation of cell wall-deficient cells in filamentous actinomycetes
K. Ramijan, E. Ultee, J. Willemse, Z. Zhang, J. A. J. Wondergem, A. van der Meij, D. Heinrich, A. Briegel, G. P. van Wezel, D. Claessen
DOI
The ISME Journal · 2017
The evolution of no-cost resistance at sub-MIC concentrations of streptomycin in Streptomyces coelicolor
S. Westhoff, T. M. van Leeuwe, O. Qachach, Z. Zhang, G. P. van Wezel, D. E. Rozen
DOI
Frontiers in Microbiology · 2016
Understanding microbial divisions of labor
Z. Zhang, D. Claessen, D. E. Rozen
DOI
Xenobiotica · 2013
Cloning and functional characterization of the pig (Sus scrofa) organic anion transporting polypeptide 1a2
Y. Yu, X. Liu, Z. Zhang, Y. Xiao, M. Hong
DOI
Drug Metabolism and Disposition · 2013
Identification of multiple binding sites for substrate transport in bovine organic anion transporting polypeptide 1a2
X. Liu, J. Huang, Y. Sun, K. Zhan, Z. Zhang, M. Hong
DOI
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